Splicing uncoupled
نویسندگان
چکیده
منابع مشابه
Single-Molecule Imaging of Transcriptionally Coupled and Uncoupled Splicing
Introns are removed from pre-mRNAs during transcription while the pre-mRNA is still tethered to the gene locus via RNA polymerase. However, during alternative splicing, it is important that splicing be deferred until all of the exons and introns involved in the choice have been synthesized. We have developed an in situ RNA imaging method with single-molecule sensitivity to define the intracellu...
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Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic transcription is first detected shortly after pronucleus formation in 1-cell embryos, but the identity of the transcribed loci and mechanisms regulating their expression are not known. Using total RNA-Seq, we have found that transcription in 1-cell embryos is highly promiscuous, such that intergenic regions ar...
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Dynamics in a distributed system are self-stabilizing if they are guaranteed to reach a stable state regardless of how the system is initialized. Game dynamics are uncoupled if each player’s behavior is independent of the other players’ preferences. For uncoupled players, recognizing an equilibrium is a distributed computational task. Self-stabilizing uncoupled dynamics, then, capture both resi...
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Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2009
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2626